Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
SIRT1, resveratrol and aging
Aging is linked to a time-associated decline in both cellular function and repair capacity leading to malfunction on an organismal level, increased frailty, higher incidence of diseases, and death. As the population grows older, there is a need to reveal mechanisms associated with aging that could spearhead treatments to postpone the onset of...
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